Tryptophan metabolism in the synovial fluid in rheumatoid arthritis and osteoarthritis.
نویسندگان
چکیده
Tryptophan and its intermediate metabolites in the synovial fluid were studied in order to know a specificity of the tryptophan metabolism in rheumatoid arthritis and osteoarthritis. A metabolic map was made, and the pathways of tryptophan breakdown in both diseases were compared. It was found that tryp tophan in rheumatoid arthritis was metabolized mainly to anthranilic acid through kynurenine, whereas in osteoarthritis the pathway of kynurenic acid and nicotinic acid was characteristic.
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ورودعنوان ژورنال:
- The Tohoku journal of experimental medicine
دوره 99 1 شماره
صفحات -
تاریخ انتشار 1969